تاثير درماننوكوليتيك در مقابل درمان انتظاري در بيماران پره ترم باپارگي زودرس كيسه آب

Preterm Premature Rupture of Membranes: Aggressive Tocolysis Versus Expectant Management

Objectives: The purpose of this randomized, prospective study was to evaluate the efficacy of tocolysis in the prolongation of pregnancy and neonatal outcome in the preterm premature rupture of the membranes (PPROM). Materials and Methods: Patients with documented PPROM between 26 and 36 weeks gestation were prospectively randomized to group 1: aggressive tocolysis with intravenous magnesium sulfate, or to group II: no tocolysis. Both groups received weekly steroids and antibiotics. The study group involved in 80 patients. Results: Magnesium sulfate was successful in suppressing preterm labor in PPROM, deliveries within 48 hours (40% versus 75%) and a week (92% versus 65%) of PPROM occurred more frequently in the expectant management group. Tocolysis was not effective in the method of delivery. There were no relations between gestational age and results of tocolytic management. Magnesium sulfate therapy did not appear to improve neonatal outcome. Conclusion: Our data suggest that tocolysis in PPROM increases intrauterine time but doesnʹt improve neonatal outcome.