افزايش اثر بي دردي ليدوكايين در بي حسي نخاعي با اضامه نمودن كلونيدين

Increasing the Analgesic Effect of Lidocaine in Spinal Anesthesia with Clonidine

The widespread use of spinal anesthesia in various operations necessitates long acting anesthetic drugs with a low incidence of complications. lidocaine is an effective drug with low side effects but has no long-acting effects. Sympathomimetics and narcotics can increase and potentiate the time and quality of lidocaine anesthesia. In this randomized clinical trial, the effects of intraspinal clonidine on the time and quality of lidocaine spinal anesthesia was studied. Among the orthopedic or abdominal surgeries, 60 patients were selected and randomly divided in two equal groups The first group had spinal anesthesia with lidocaine and clonidine and the second lidocaine only. The results that were analyzed with the student t-test. In the first group, mean analgesia time was significantly longer [150-180 min. VS 60-90 min] in comparison to the other group (Lidocaine only). Furthermone the quality of analgesia was better in the first group. The most common side effect was greater hypotention in the second group. These findings show that administration of clonidine with lidocaine in spinal anesthesia, causes prolongation and potentiation of spinal anesthesia and has lower side effects. This results in lowered general anesthesia use in patients where narcotics and sympathomimetics are contraindicated, clonidine is a good alternative for prolongation of lidocaine spinal anesthesia.