بررسي نقش سم عقرب همي سكورپيويس لپتروس در شكنندگي گلبولهاي قرمز

Role of Hemiscorpius Lepturus Venom on Red Blood Cell Fragility

Hemiscorpius lepturusʹs habitat is in six southern provinces in IRAN and is considered as one of the most dangerous scorpion genera and a major cause of death by scorpion bite in khoozestan and hormozgan provinces. The most important clinical symptoms of this scorpion bite are deep necrotic wounds, ankylosis, temporary or permanent psychosis, hemolysis and kidney failure. Sever or mild hemolysis usually occurs afrer Hemiscorpious lepturus bite, and according to previous studies the sever form which more frequent among children is in the form of hemoglobinoria. In the present study we investigated the effect of Hemiscorpius lepturus venom on human red blood cells in vitro. We also tried to show and compare the fragility effect of venom on RBC in different mammals other than human and avian species such as chicken. Our results show all blood groups of human were sensitive to the venom effect and were fragile. Among four mammals (cow, horse, sheep and goat) and chicken, the RBC of cow was the most sensitive and goat and chiken RBC showed less sensitivy to hemolysis.