سنتز و فرمولاسيون دي متيل فتالات به عنوان دافع حشرات

Synthesis and formulation of dimethyl phthalate as an insect repellent

Background and Aim: Prior to 1940 the commonly used insect repellent materials were substances such as citronella oil, clove oil and camphor. The outbreak of the world war II and the need for conducting operations in many tropical areas led to an exhaustive investigation and consequently making many effective insect repellents. Among the best known substances was dimethyl phthalate. The aim of this study was to synthesize of dimethyl phthalate as a drug formulation. Method: Reaction of phthalic anhydride with absolute methanol in catalytic amount of concentrated H2SO4 produced dimethyl phthalate. This compound was formulated as a hydroalcoholic lotion and as a gel. Several gel and lotions with suitable stability were formulated. Results: Dimethyl phthalate was synthesized with 96% yield its viscosity was sutable. Conclusion: It is possible to synthesize dimethyl phthalate from low-cost materials and formulate it to pharmaceutical preparations (e.g. Lotion or Creams), in our country.