مقايسه نتايج آزمون ويسكانسين در بيماران اسكيزوفرن مبتلا و غيرمبتلا به حركت پريشي ديررس ، بستري در بيمارستان هاي ابن سينا و حجازي مشهد

The comparison of WCST in schizophrenic patients with and without tardive dyskinesia(in patient in Ebnesina and Hegazi hospital)

Tardive dyskinesia (T.D) is a neurological movement disorder. It is induced by neuroleptic drugs but at least some of these movement are due to dysfunction of frontal lobe in schizophrenic patients. in this research, we assessed the function of prefrontal area in schizophrenic patients with and without T.D to answer the following questions: Is there any relationship between T.D and dysfunction of frontal lobe? Is there any way to recognize patients that are vulnerable to T.D and to prevent it? In this research 100 schizophrenic in-patients were chosen (50 with T.D and 50 without it). They were assessed with "WCST" that is a standard neuropsycologic test for assessment of prefrontal function. Results were statistically analyzed with t-test and Chi-square, SPSS. Pationts with T.D compared to patients without T.D had segnificantly (P - 0) increased errors in "WCST" that showed dysfunction of frontal lobe in patients with T.D. it appears with WCST in early stages of schizophrenia we can recognise patients with dysfunction of frontal lobe and vulnerable to T.D and prevent development and progression of T.D with atypical antipsychotics and regular monitoring of abnormal movements in these patients.