مقايسه اثر هالوپريدول عضلاني و لورازپام خواركي با رسپيريدون و لورازپام خوراكي در درمان بي قراري حاد روان پريشانه

The comparative efficacy of Haloperidol (IM) plus Lorazepam (PO)and Risperion plus Lorazepam in the management of acute agitation

High prevalence of acute psychotic agitation in psychiatric emergency centers, necessiates finding an medication with less side effects and more efficacy. Concerning the reports about the efficacy of atypical antipsychotics (even in oral route) in shch cases. We decided to examine the efficacy of these drugs in comparisson with older ones (oral resperidon plus lorazepam and haloperidol (1M) plus lorazepams. The sample population included 60 acute psychotic agitaed patients admitted to emergency room of Ebne-Sina psychiatric center. The exclusion criteria were seizure disorder pregnancy - substance abuse, developmental disorders and other major medical problems. These patients were randomly divided in two groups. The first group was given haloperidol (5mg/Im) plus lorazepam (2mg/po) and in the second group, risperidon (2mg/po) plus lorazepam (2mg/po) were administered remission was assesed based on the total score and scores of subclasses of PANSS incuding: hostility - incooperativeness hallucinatory behaviors - implus dyscontrol and excitement on time zero, 30 and 60 munutes. The results were analyzed using the proper test analyzer. Significant decrease in PANSS scores were observed in each group (P<0.001). There was no significatn differences in total score and scores of subclasses between two groups. 3 patients of each group needed aditional dose 1 hour after the first one. The mean time to induce sleep in haloperidol group was 60 minutes (SD: 33m) and iii the resperidon group 55 minutes (SD: 34m). The present study similar to previous ones showed that the efficacy risperidon plus lorazepam (po) in the control psychotic agitators was equal to that of intramuscular haloperidol plus oral lorazepam.