تغييرات برخي از شاخص هاي سوخت وساز استخوان در پركاري تيروييد ناشي از بيماري گريوز

Evaluation of some of the metabolic bone index during hyperthyroidism

Increase blood level of thyriod hormones due to hyperthyriodism can change the balance between resorption and bone formation and result in hypercalcemia, increase alkaline phosphatase and increase in urinary calcium excretion. Due to these finding and the nutritional conditions of our country in calcium containing food, we dicided to evaluate some of bone indexes in hyperthyriod patients. 30 women. 6 men between 17-40 years (23 patients) and more than 40 years (13 patients) were the sample papulations. The control subjects were 35 healthy people 17-40 years (25 persons) and more than 40 years (10 persons). The serum calcium, phosphorus and alkaline phosphatase were determined in these hyperthyriod patients. There were a meaningful correlation between the alkaline phosphatase of hyperthyriod patients compared to normal subject (P<0.05) in the patients more than 40 years old, and P<0.01 in the 17-40 years patients. There were no differences between serum calcium of hyperthyroid patients and normal subjects. The results from this investigation indicat that in hyperthyroid patients the avarage alkaline phosphatase level is higher than normal subjects. On the other hand the reason for not having a meaningful differences n calcium level between the hyperparathyriod patients and normal population may be due to low dietry intake of dairy product and proteins in daily diet which results in low amount of calcium in nutrition.