كانديد عمل جراحي انتخابي ASA1 ميزان اثر روكرونيوم روي ثبات فشارخون متوسط شرياني و ضربان قلب در بيماران

Effect of rocuronium on mean arterial pressure & heart rate in undergoing elective surgical patients ASA1

Background and Objectives: From 1942 when Griffth & Johnson suggested that muscle relaxants are safe drugs for better laryngoscopy & intubation and good for skeletal muscle relaxation during surgery, many of muscle relaxants discovered with different effect, side effect and potency. Some of the muscle relaxants properties include rapid onset, shortacting, fast recovery, stablity of hemodynamic, lock of histamine release and etc. hemodynamic stability is one of the important properties of this drug. In this reseach we wanted to see effect of rocuronium which is an intermediate muscle relaxant on systolic, diastolic B.P and H.R of patient who is candidate for elective surgery. Patients and Methods: This research is an experimental study. We wanted to see the effects of Rocuronium that is an intermediate muscle relaxant on mean avierial pressure and heart rate of the patient who is coming to the hospital of Iran medical university hospitals for elective orthopedic surgery. The sample size calculated 30 pateints. We choose our patients with simple randomize method. All of them were ASA 1 and in the age of 20 to 50 years old. The patients didnʹt receive any pre-medication until coming to oprerating room. In the OR they recived 7cc/kg ringer solution and then 70 µg/kg thalamonal was administerd intravenously. Five minute latter their BP and PR was cheked, which considered basline measurment. Induction of anesthesia was with tiopental 5mg/kg and rocuronium 0.9mg/kg. After 60 sec patients were intubated with direct laryngoscopy. The maintenance of anesthesia for first 10 minutes was with 02 50% and N20 50% and for continue of anesthesia M.R and opioid depend on need. Results: We analyzed our data with paired to t-test and Green house test. Systolic and diastolic blood pressure and heart rate changes was 5% lowest than baseline hemodynamic parameter. Conclusion: With attention to pervious studies and observation of hemodynamic changes with muscle relaxants which uses in Iran, this drug (rocuronium) have good effect on stability of hemodynamic parameters. Beside other property of Rocuronium include. Rapid onset, lack of histamine release, intermediate acting and etc. we can said this drug is a good and safe muscle relaxant for use during anesthesia and surgery.