مقايسه تاثير ژل زنجبيل و ژل پيروكسيكام بر كاهش ميزان درد استئوآرتريت زانو

Comparison the effects of ginger (Zingiber officinale) jelly and piroxicam jelly on pain of knee osteoarthritis

زمينه و هدف: مصرف داروهاي خوراكي و داروهاي ضد التهاب غير استروئيدي براي كاهش درد استئوآرتريت زانو عوارضي را بدنبال دارد. هدف اين مطالعه بررسي تاثير احتمالي داروي گياهي ژل زنجبيل بر كاهش ميزان درد، خشكي صبحگاهي و عملكرد فيزيكي در مبتلايان به استئوآرتريت زانو و مقايسه با ژل پيروكسيكام مي باشد. روش بررسي: در اين مطالعه تجربي، 120بيمار مبتلا به استئو‌آرتريت به صورت تصادفي در 3گروه 40نفره تقسيم شدند. يك گروه ژل زنجبيل2% ، دو گروه ديگر به ترتيب ژل پيروكسيكام و پلاسبو دريافت كردند. به هر سه گروه قرص ديكلوفناك يكبار در روز و ژل مورد نظر دوبار در روز براي مدت14 روز تجويز شد. معاينه اول بيماران در هنگام مراجعه به پزشك و معاينه دوم 2هفته بعد از انجام مداخله صورت پذيرفت و ميزان درد بر اساس مقياس [1]VAS بررسي شد. همچنين از شاخص [2]WOMAC جهت ارزيابي تاثير درد بر عملكرد بيماران استفاده شد. داده ها با نرم افزار آماري SPSS و آزمون هاي آماري t زوجي، كاي اسكوئر و آناليز واريانس تحليل شدند. يافته‌ها: ژل زنجبيل باعث كاهش ميزان كلي درد و خشكي صبحگاهي بيماران شد. اين كاهش در مقايسه با گروه دريافت كننده ژل پيروكسيكام اختلاف معني داري نداشت (0/05

Background and Aim: Oral drugs and nonsteroidal anti-inflammatory drugs which are used to relieve pain are associated with certain side effects in the patients with knee osteoarthritis. The aim of this study was to compare the effects of a herbal drug, Zingiber officinale jelly, and piroxicam jelly on pain relief, morning stiffness, and physical performance in the patients with knee osteoarthritis. Material and Methods: In this semi-experimental study one hundred and twenty patients with osteoarthritis were randomly assigned to three groups of 40. Z. officinale 2% jelly, piroxicam jelly, and placebo were given twice a day for 14 days to the 1st, 2nd and 3rd groups respectively. Concurrently, diclofenac tablet 100mg/ day was given to all groups. Physical examination was performed before intervention and two weeks after completion of the treatment. The level of pain was measured by use of visual analogue scale. Furthermore, the WOMAC index was used to investigate the effect of pain on the patients' performance. Using SPSS software, data were analyzed by paired t-test, chi-square and ANOVA. Result: There were no significant difference between Z. officinale jelly and piroxicam jelly in relation to relief of overall pain and morning stiffness, (P>0.05). The relief of pain (P=0.01) and morning stiffness (P=0.002) were significantly more marked in the piroxicam-treated group compared to those in the placebo group. Improvement of the physical functioning was not significantly different between the piroxicam-treated and Z. officinale-treated groups (P>0.05). Conclusion: Z. officinale jelly and piroxicam jelly were effective in pain relief, amelioration of morning stiffness, and improvement of physical functioning in the patients with knee osteoarthritis, and there were no significant differences between the effects of the jellies.