بر اساس پديدآور

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Morris، M. D. نويسنده , ◄ Testi، L. نويسنده , ◄ Genzel، R. نويسنده , ◄ Robin، A. C. نويسنده , ◄ Schultheis، M. نويسنده , ◄ Omont، A. نويسنده , ◄ Schuller، F. نويسنده , ◄ Ojha، D. K. نويسنده , ◄ Epchtein، N. نويسنده , ◄ Blommaert، J. A. D. L. نويسنده , ◄ Groenewegen، M. A. T. نويسنده , ◄ Habing، H. J. نويسنده , ◄ Teyssier، D. نويسنده , ◄ Joshi، U. C. نويسنده , ◄ Baliyan، K. S. نويسنده , ◄ Ganesh، S. نويسنده , ◄ Ott، S. نويسنده , ◄ Hennebelle، P. نويسنده , ◄ Kimeswenger، S. نويسنده , ◄ Fouque، P. نويسنده , ◄ Parthasarathy، M. نويسنده , ◄ Alard، C. نويسنده , ◄ Simon، G. نويسنده , ◄ Borsenberger، J. نويسنده , ◄ Felli، M. نويسنده , ◄ Perault، M. نويسنده , ◄ Cesarsky، C. J. نويسنده , ◄ Copet، E. نويسنده , ◄ Messineo، M. نويسنده , ◄ Moneti، A. نويسنده , ◄ Aracil، B. نويسنده , ◄ Soive، A. نويسنده , ◄ Gilmore، G. F. نويسنده , ◄ August، T. نويسنده , ◄ Beaulieu، S. نويسنده , ◄ Begon، S. نويسنده , ◄ Bertou، X. نويسنده , ◄ Burgdorf، M. نويسنده , ◄ Caillaud، B. نويسنده , ◄ Chitre، A. نويسنده , ◄ Batz، B. de نويسنده , ◄ Egan، M. P. نويسنده , ◄ Egret، D. نويسنده , ◄ Glass، I. S. نويسنده , ◄ Gredel، R. نويسنده , ◄ Guglielmo، F. نويسنده , ◄ Jiang، B. نويسنده , ◄ Miville-Deschênes، M. A. نويسنده , ◄ Ortiz، R. نويسنده , ◄ Price، S. D. نويسنده , ◄ Tiphène، D. نويسنده , ◄ Unavane، M. نويسنده , ◄ Loon، J. T. van نويسنده , ◄ Wyse، R. نويسنده ,
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Mortaz ، Esmaeil Department of Immunology - Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), School of Medicine - Shahid Beheshti University of Medical Sciences ► Jamaati ، Hamidreza Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD) - Shahid Beheshti University of Medical Sciences ► K.Dezfuli ، Neda Center for Vaccine Development - School of Medicine - University of Maryland ► Sheikhzade ، Hakime Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD) - Shahid Beheshti University of Medical Sciences ► Hashemian ، MohammadReza Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD) - Shahid Beheshti University of Medical Sciences ► Roofchayee ، Neda Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD) - Shahid Beheshti University of Medical Sciences ► Dastan ، Frazaneh Department of Clinical Pharmacology - Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Faculty of Pharmacy - Shahid Beheshti University of Medical Sciences ► Tabarsi ، Payam Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD) - Shahid Beheshti University of Medical Sciences ► Folkerts ، Gert Division of Pharmacology - Utrecht Institute of Pharmaceutical Sciences, Faculty of Science - Utrecht University ► Garssen ، Johan Division of Pharmacology, Department of Immunology - Utrecht Institute of Pharmaceutical Sciences, Faculty of Science - Utrecht University ► Mumby ، Sharon National Heart and Lung Institute - Imperial College London ► Adcock ، Ian National Heart and Lung Institute - Imperial College London
625
Mortaz ، Esmaeil Department of Immunology - School of Medicine, Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD) - Shahid Beheshti University of Medical Sciences ► Dalil Roofchayee ، Neda Department of Immunology - School of Medicine, Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD) - Shahid Beheshti University of Medical Sciences ► Jamaati ، Hamidreza Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD) - Shahid Beheshti University of Medical Sciences ► Varaham ، Mohammad Mycobacteriology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD) - Shahid Beheshti University of Medical Sciences ► Abtahian ، Zahra Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD) - Shahid Beheshti University of Medical Sciences ► Afshar ، Babak Department of Immunology - School of Medicine, Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD) - Shahid Beheshti University of Medical Sciences ► Rekabi ، Mahsa Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD) - Shahid Beheshti University of Medical Sciences ► Adcock ، Ian National Heart and Lung Institute, Imperial College London - Imperial College London ► Tabarsi ، Payam Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD) - Shahid Beheshti University of Medical Sciences
629
Mortaz, Esameil Chronic Respiratory Diseases Research Center and National Research Institute of Tuberculosis and Lung Diseases (NRITLD) - Department of Immunology - Shahid Beheshti University of Medical Sciences, Tehran ► Gudarzi, Hoda Chronic Respiratory Diseases Research Center and National Research Institute of Tuberculosis and Lung Diseases (NRITLD) - Department of Immunology - Shahid Beheshti University of Medical Sciences, Tehran ► Tabarsi, Payam Clinical Tuberculosis and Epidemiology Research Center - National Research and Institute of Tuberculosis and Lung Diseases (NRITLD) - Shahid Beheshti University of Medical Sciences, Tehran ► Adcock, Ian M. AirwaysDisease Section - National Heart and Lung Institute - Imperial College London, London, UK ► Masjedi, Mohamad Reza Chronic Respiratory Diseases Research Center and National Research Institute of Tuberculosis and Lung Diseases (NRITLD) - Department of Immunology - Shahid Beheshti University of Medical Sciences, Tehran ► Jamaati, Hamid Reza Chronic Respiratory Diseases Research Center and National Research Institute of Tuberculosis and Lung Diseases (NRITLD) - Department of Immunology - Shahid Beheshti University of Medical Sciences, Tehran ► Garssen, Johan Division of Pharmacology - Utrecht Institute for Pharmaceutical Sciences - Faculty of Science - Utrecht University, Utrecht, The Netherlands ► Velayati, Ali Akbar Mycobacteriology Research Center (MRC) National Research Institute of Tuberculosis and lung diseases (NRITLD) - Shahid Beheshti University of Medical Sciences, Tehran ► Redegeld, Frank A. Division of Pharmacology - Utrecht Institute for Pharmaceutical Sciences - Faculty of Science - Utrecht University, Utrecht, The Netherlands
785
Mortazavi, Alireza Department of pharmaceutics, School of pharmacy, Shaheed Beheshti University of Medical Sciences and Health Services, Tehran ► Mokarram, Ali Rezaei Preparation of chitosan (CS) microspheres as a novel drug delivery vehicle for intranasal immunization using high, medium and low CS molecular weight (MW) was investigated in this study. Diphtheria toxoid (DT) was used as a model antigen. The emulsion-solidification method was adopted for microencapsulation of DT. In the first step, following the purification of semi-crude DT by the ion-exchange column chromatography technique, the antigenicity and biological characteristics of DT were investigated by the bicinchoninic acid protein assay, ELISA and western blot techniques. Results showed that the purification process was successful and the purified toxoid gave an activity of 1500 Lf/ml; which was three times more than that of the semi-crude toxoid. Next, DT-loaded microspheres were prepared and characterized for their surface morphology, particle size distribution, loading efficiency and invitro antigenically active DT release. This study showed that the loading efficiency of CS microspheres depends on the MW, as well as the type of cross-linker used, such that, microspheres prepared by high MW CS and glutaraldehyde (cross-linking agent) had the highest DT loading level (95.61±3.57 percent). Size distribution studies showed that the particle size of microspheres prepared by low and medium MW CS solutions with a concentration of 1 %w/v was below 10 mm. These microspheres also had a smoother surface morphology than those prepared using high MW CS solutions with concentrations above 1 %w/v. In addition, by investigating the antigenicity of the prepared CS microsphere, no significant reduction in the activity of DT before and after microencapsulation was noted. Finally, in-vitro release studies showed an initial burst effect followed by an extended release of antigenically active DT over a period of 15 days.